Zixuan Jiang

1 month ago | opg.optica.org | Weiping Qin |Fanchao Meng |Yu Yang |Zixuan Jiang

Nanoparticle (NP)-doped polymer waveguide devices have attracted increasing interest in some rapidly developing areas of broadband communications because they are easy to integrate on chip. As an important part of the gain medium of waveguide amplifiers, lanthanide-doped nanoparticles have been widely studied to improve the amplification performance of devices. However, current research work is almost limited to erbium-doped nanoparticles and amplifiers operating in the C-band.

2 months ago | pubs.acs.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan

2 months ago | dx.doi.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan

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Oct 12, 2024 | biorxiv.org | Zixuan Jiang |Sitao Zhang |Jiahang Cao |Qiang Zhang

AbstractReliable datasets and high-performance models work together to drive significant advancements in protein representation learning in the era of Artificial Intelligence. The size of protein models and datasets has grown exponentially in recent years. However, the quality of protein knowledge and model training has suffered from the lack of accurate and efficient data annotation and cleaning methods.

Oct 1, 2024 | biorxiv.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan

AbstractMolecular glue degraders (MGDs) are small molecules that facilitate proximity between a target protein and an E3 ubiquitin ligase thereby inducing target protein degradation. Glutarimide-containing compounds are MGDs that bind to cereblon (CRBN) and recruit neosubstrates. Through explorative synthesis of a glutarimide-based library, we discovered a series of molecules that induce casein kinase 1 alpha (CK1α) degradation.