Rachel A. Ridgway

3 weeks ago | nature.com | Eoghan J. Mulholland |Hayley L. Belnoue-Davis |Aik Seng Ng |Kim S. Midwood |Neesha Dedi |Rachel A. Ridgway | +6 more

AbstractIn homeostasis, counterbalanced morphogen signalling gradients along the vertical axis of the intestinal mucosa regulate the fate and function of epithelial and stromal cell compartments. Here, we use a disease-positioned mouse and human tissue to explore the consequences of pathological BMP signalling dysregulation on epithelial-mesenchymal interaction.

Jun 3, 2024 | nature.com | Sudhir B. Malla |Ryan Byrne |Natalie Fisher |Petros Tsantoulis |Rachel A. Ridgway |Kathryn L. Gilroy | +17 more

Correction to: Nature Genetics https://doi.org/10.1038/s41588-024-01654-5, published online 13 February 2024In the version of the article initially published, the S:CORT consortium was missing from the author list and has now been added to the HTML and PDF versions of the article.

Aug 14, 2023 | nature.com | Johan Vande Voorde |Rory T. Steven |Arafath K. Najumudeen |Chelsea J. Nikula |Yuchen Xiang |Lauren Ford | +22 more

AbstractThe genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models, and multimodal mass spectrometry-based metabolomics to study the impact of common genetic drivers of CRC on the metabolic landscape of the intestine.