Ralph J. DeBerardinis

Dec 5, 2024 | cell.com | Ruilong Liu |Xuelian Ren |Yae Eun Park |Huixu Feng |Xinlei Sheng |Xiaohan Song | +12 more

1State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China 2Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA 3Comprehensive Cancer Center, The University of Chicago, Chicago, IL 60637, USA 4School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China 5Biological Science Division,...

May 20, 2024 | nature.com | Emily Parks |Jiwoong Kim |Andrew Lemoff |Lin Xu |Jerry W. Shay |Ralph J. DeBerardinis | +1 more

AbstractCancer cells exhibit distinct metabolic activities and nutritional dependencies compared to normal cells. Thus, characterization of nutrient demands by individual tumor types may identify specific vulnerabilities that can be manipulated to target the destruction of cancer cells. We find that MYC-driven liver tumors rely on augmented tryptophan (Trp) uptake, yet Trp utilization to generate metabolites in the kynurenine (Kyn) pathway is reduced.

Feb 29, 2024 | biorxiv.org | Ling Cai |Ying Gao |Ralph J. DeBerardinis |Ting Chen

AbstractLung cancer, the leading cause of cancer mortality, exhibits diverse histological subtypes and genetic complexities. Numerous preclinical models have been developed to study lung cancer, but data from these models are disparate, siloed, and difficult to compare in a centralized fashion. Here we established the Lung Cancer Mouse Model Database (LCMMDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets.

Aug 12, 2023 | cell.com | Arthur Riggs Diabetes |Ralph J. DeBerardinis

Highlights•Reductive carboxylation occurs in the absence of lipogenesis•FASN deficiency induces reductive carboxylation•FASN deficiency induces a net cytosol-to-mitochondria citrate flux•Malignant cells trade off lipogenesis-supported rapid growth for redox capacitySummaryFatty acid synthase (FASN) maintains de novo lipogenesis (DNL) to support rapid growth in most proliferating cancer cells.