Jiwoong Kim

May 21, 2024 | nature.com | Shuai Tan |Colin Bergstrom |Gonçalo Vale |Jeffrey McDonald |Andrew Schmidt |Nguyen Vo | +4 more

AbstractNutrient handling is an essential function of the gastrointestinal tract. Hormonal responses of small intestinal enteroendocrine cells (EECs) have been extensively studied but much less is known about the role of colonic EECs in metabolic regulation. To address this core question, we investigated a mouse model deficient in colonic EECs. Here we show that colonic EEC deficiency leads to hyperphagia and obesity.

May 20, 2024 | nature.com | Emily Parks |Jiwoong Kim |Andrew Lemoff |Lin Xu |Jerry W. Shay |Ralph J. DeBerardinis | +1 more

AbstractCancer cells exhibit distinct metabolic activities and nutritional dependencies compared to normal cells. Thus, characterization of nutrient demands by individual tumor types may identify specific vulnerabilities that can be manipulated to target the destruction of cancer cells. We find that MYC-driven liver tumors rely on augmented tryptophan (Trp) uptake, yet Trp utilization to generate metabolites in the kynurenine (Kyn) pathway is reduced.

Jan 19, 2024 | science.org | Chiho Kim |Xu-Dong Wang |Zhengshuai Liu |Jianwei Hao |Shuai Wang |Peng Li | +11 more