Rebecca Shipley

May 21, 2024 | onlinelibrary.wiley.com | Paul Sweeney |Claire Walsh |Simon Walker-Samuel |Rebecca Shipley

1 INTRODUCTION The microcirculation is a hierarchical structure of blood vessels consisting of arterioles, capillaries and venules. These vessels are typically classified as those with diameters < 300 $$ <300 $$ μm and by several distinctive characteristics, such as mural cell coverage1 and resistance to flow.2 Structurally, arterioles and venules form branching structures which supply and drain an interconnected, mesh-like network of capillaries with diameters < 10 $$ <10 $$ μm.

Feb 7, 2024 | biorxiv.org | Paul Sweeney |Claire Walsh |Simon Walker-Samuel |Rebecca Shipley

AbstractWe present a 3D discrete-continuum model to simulate blood pressure in large microvascular tissues in the absence of known capillary network architecture. Our hybrid approach combines a 1D Poiseuille flow description for large, discrete arteriolar and venular networks coupled to a continuum-based Darcy model, point sources of flux, for transport in the capillary bed.