René S. Kahn

Jun 1, 2024 | ajp.psychiatryonline.org | René S. Kahn

The more things change, the more they stay the same, as the French expression goes (Plus ça change, plus c’est la même chose), and thus it is with the results of the study reported by Tramazzo et al. in this issue of the Journal (1), where they conclude that clinical outcome is poor among patients with schizophrenia. So, what’s new? Didn’t we know this already? Kraepelin defined the illness, then called dementia praecox, based on the poor outcome he observed in his patients (2).

Dec 1, 2023 | nature.com | Celso Arango |Richard Dinga |Birte Glenthøj |René S. Kahn |Robin Murray |Carmine Pariante | +2 more

AbstractThere is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psychosis. A major barrier to developing useful markers for this is biological heterogeneity, where many different pathological mechanisms may underly the same set of symptoms in different individuals.

May 5, 2023 | nature.com | Dominic B. Dwyer |Alessandro Pigoni |Junhao Wen |Gyujoon Hwang |Guray Erus |René S. Kahn | +11 more

AbstractUsing machine learning, we recently decomposed the neuroanatomical heterogeneity of established schizophrenia to discover two volumetric subgroups—a ‘lower brain volume’ subgroup (SG1) and an ‘higher striatal volume’ subgroup (SG2) with otherwise normal brain structure.