Robyn Guymer

Jul 20, 2024 | nature.com | Keean Nanji |Amin Hatamnejad |Mark Phillips |Dena Zeraatkar |Tien Yin Wong |Robyn Guymer | +8 more

The fragility index (FI) of a meta-analysis evaluates the extent that the statistical significance can be changed by modifying the event status of individuals from included trials. Understanding the FI improves the interpretation of the results of meta-analyses and can help to inform changes to clinical practice. This review determined the fragility of ophthalmology-related meta-analyses. Meta-analyses of randomized controlled trials with binary outcomes published in a journal classified as ‘Ophthalmology’ according to the Journal Citation Report or an Ophthalmology-related Cochrane Review were included. An iterative process determined the FI of each meta-analysis. Multivariable linear regression modeling evaluated the relationship between the FI and potential predictive factors in statistically significant and non-significant meta-analyses. 175 meta-analyses were included. The median FI was 6 (Q1–Q3: 3–12). This meant that moving 6 outcomes from one group to another would reverse the study’s findings. The FI was 1 for 18 (10.2%) of the included meta-analyses and was ≤5 for 75 (42.4%) of the included meta-analyses. The number of events (p < 0.001) and the p-value (p < 0.001) were the best predictors of the FI in both significant and non-significant meta-analyses. The statistical significance of meta-analyses in ophthalmology often hinges on the outcome of a few patients. The number of events and the p-value are the most important factors in determining the fragility of the evidence. The FI is an easily interpretable measure that can supplement the reader’s understanding of the strength of the evidence being presented. CRD42022377589

Jul 1, 2024 | onlinelibrary.wiley.com | Robyn Guymer

EDITORIAL Ageing and retinal thickness: An important association Robyn H. Guymer FRANZCO, PhD,  Corresponding Author Robyn H. Guymer FRANZCO, PhD Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia Correspondence Robyn H. Guymer, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Vic., Australia.

May 7, 2024 | ophthalmologyscience.org | Himeesh Kumar |East Melbourne |Robyn Guymer |Lauren Hodgson

ABSTRACTTo understand the spatial relationship between local rod-mediated visual function and reticular pseudodrusen (RPD) in eyes with large drusen. Retrospective cross-sectional study. One eye with large drusen (>125μm) each from 91 individuals with intermediate age-related macular degeneration (AMD), with and without RPD.

Apr 3, 2024 | mivision.com.au | Robyn Guymer

Both currently approved drugs work to block the complement pathways in the eye by way of regular intravitreal injection.

Mar 1, 2024 | retinalphysician.com | Robyn Guymer |Zhichao Wu

The Beckman classification of age-related macular degeneration (AMD), based on color fundus photography (CFP), offers an accessible, easy-to-determine severity scale.1 In the Beckman classification, AMD is categorized as early, intermediate, or late-stage disease and the 2 late forms of AMD are neovascular (nAMD) and geographic atrophy (GA). The past decade has seen interventional studies aiming to slow the progression of disease, but only once GA was already present.