Zhichao Wu

Dec 6, 2024 | mdpi.com | Zhichao Wu |Changyun Wei |Yu Xia |Ze Ji

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Mar 1, 2024 | retinalphysician.com | Robyn Guymer |Zhichao Wu

The Beckman classification of age-related macular degeneration (AMD), based on color fundus photography (CFP), offers an accessible, easy-to-determine severity scale.1 In the Beckman classification, AMD is categorized as early, intermediate, or late-stage disease and the 2 late forms of AMD are neovascular (nAMD) and geographic atrophy (GA). The past decade has seen interventional studies aiming to slow the progression of disease, but only once GA was already present.

Jan 29, 2024 | onlinelibrary.wiley.com | Zhichao Wu |Lauren Hodgson |Robyn Guymer |Jan H. Terheyden

1 INTRODUCTION A major challenge in the evaluation of new interventions to slow or prevent the development of late age-related macular degeneration (AMD) complications in its early stages is the need for large and lengthy trials given the slowly progressive nature of this disease.1, 2 Biomarkers that could be used to identify high-risk individuals to target in such trials, and/or act as earlier surrogate endpoints for progression to the conventional, gold-standard clinical endpoint of...

Dec 13, 2023 | onlinelibrary.wiley.com | Zhichao Wu |Senuri Karunaratne |Keith Martin |Laura E. Downie

1 INTRODUCTION Glaucoma is an optic neuropathy characterised by progressive degeneration of retinal ganglion cells (RGCs), characteristic changes in optic nerve and neuroretinal tissue structure, and associated visual sensitivity deficits.

Oct 31, 2023 | frontiersin.org | Zhichao Wu

Gene regulation is the intricate and highly dynamic process of inducing or inhibiting the expression of individual genes in an organism’s genome. It is orchestrated by a vast array of molecules, including transcription factors and cofactors, chromatin regulators, as well as other epigenetic mechanisms, which allow an organism to control cell growth and differentiation during development.