Roland H. Stimson

Nov 4, 2024 | onlinelibrary.wiley.com | Roland H. Stimson |Anna R Dover |Marcus Lyall

Omnipod 5 (OP5) is a tubeless automated insulin delivery (AID) system that was, until recently, only compatible with Dexcom G6 sensors (G6). Currently, all published evidence attesting to the efficacy of OP5 relates specifically to use with G6 sensors.1, 2 In mid-2024, OP5 compatibility with Freestyle Libre 2 Plus CGM (L2+) was launched in the United Kingdom. This study aimed to compare early glycaemic outcomes, and time spent in AID mode, between those using G6 and L2+ sensors.

Oct 11, 2024 | onlinelibrary.wiley.com | Roland H. Stimson |Diabetes Edinburgh |Anna R Dover |Rohana J Wright

Despite substantial advances in diabetes care over the previous decade, only a minority of people with type 1 diabetes achieve an HbA1c <53 mmol/mol.1 Automated insulin delivery (AID) systems have consistently demonstrated efficacy in reducing HbA1c.2 Omnipod 5 (Insulet Corp) is a tubeless AID system which was launched in the United Kingdom in 2023. Here, we report the first 1-year CGM, HbA1c and weight outcomes in people using Omnipod 5, under routine clinical care, in the United Kingdom.

Oct 10, 2024 | dom-pubs.onlinelibrary.wiley.com | Anna R Dover |Rohana J Wright |Roland H. Stimson |Diabetes Edinburgh

1 BACKGROUND Most of the evidence supporting the efficacy of the Freestyle Libre system has accrued in people with type 1 diabetes.

Aug 29, 2024 | nature.com | Rongling Wang |Amanda Coutts |Rubén García-Martín |Matthias Blüher |Christopher J Schofield |Ioannis Kourtzelis | +8 more

AbstractEnhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte deficiency of the oxygen-sensor HIF-prolyl hydroxylase (PHD2) gene overcomes BAT dormancy at thermoneutrality. Adipocyte-PHD2-deficient mice maintain higher energy expenditure having greater BAT thermogenic capacity.

Aug 31, 2023 | joe.bioscientifica.com | T’ng Choong Kwok |Roland H. Stimson |Blondin DP |Carpentier AC

Keywords: brown adipose tissue; obesity; diabetes; positron emission tomography; magnetic resonance imaging; infrared thermography; microdialysisIntroductionThe prevalence of obesity is rising worldwide, bringing with it significant morbidity and mortality (https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight). While dietary interventions are often initially successful, weight regain is typical after just a few years (Wadden et al. 1989, Knowler et al.