Rong Fan

Dec 5, 2024 | nature.com | Rong Fan

Spatial proteomics holds the potential to transform the study of proteins in situ in complex tissues, but it needs to be integrated with other layers of omics data to gain a holistic view of cellular function, heterogeneity and interactions, and the underlying mechanisms of these processes. I highlight current challenges and emerging opportunities for multi-omic spatial protein profiling to advance basic research and translational applications.

Sep 17, 2024 | avhandlingar.se | Mats Nilsson |Marco Grillo |Dan Daley |Rong Fan

Nyckelord: MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; in situ sequencing; padlock probes; rolling circle amplification; in situ hybridization; genotyping; spatial transcriptomics; molecular diagnostics; biokemi; Biochemistry; Sammanfattning: Spatially resolved transcriptomics (SRT) approaches have allowed for the investigation of transcriptomic defined cellular diversity of biological tissues previously unseen.

Jun 21, 2024 | nature.com | Yahui Long |Kok Siong Ang |Raman Sethi |Lynn van Olst |Hang Xu |Lai Guan Ng | +3 more

AbstractAdvances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of such data, we need spatially informed methods for data integration. Here, we introduce SpatialGlue, a graph neural network model with a dual-attention mechanism that deciphers spatial domains by intra-omics integration of spatial location and omics measurement followed by cross-omics integration.

Jun 2, 2024 | nature.com | Vidyani Suryadevara |Adam D. Hudgins |Alberto Pappalardo |Alla Karpova |Amit K. Dey |Birgit Schilling | +23 more

AbstractOnce considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Much of our understanding of senescent cell biology still originates from tissue culture studies, where each cell in the culture is driven to an irreversible cell cycle arrest.

Jun 29, 2023 | science.org | Hu Zeng |Graham Budd |Rong Fan

(0)eLetters eLetters is a forum for ongoing peer review. eLetters are not edited, proofread, or indexed, but they are screened. eLetters should provide substantive and scholarly commentary on the article. Embedded figures cannot be submitted, and we discourage the use of figures within eLetters in general. If a figure is essential, please include a link to the figure within the text of the eLetter. Please read our Terms of Service before submitting an eLetter. Log In to Submit a Response