Saedis Saevarsdottir

Sep 14, 2024 | nature.com | Thorunn Olafsdottir |Gudmar Thorleifsson |Abhishek Niroula |Hannes P. Eggertsson |Gísli H. Halldórsson |Folkert W. Asselbergs | +9 more

AbstractImmunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci influencing IgG subclass levels.

Feb 15, 2024 | ard.bmj.com | Eleftheria Pertsinidou |Saedis Saevarsdottir |Vivek Anand Manivel |Lars Klareskog

In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammation Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Nov 27, 2023 | ard.bmj.com | Eleftheria Pertsinidou |Saedis Saevarsdottir |Vivek Anand Manivel |Lars Klareskog

DiscussionIn our study, presence of ACPA associated with lower number of swollen and tender joints in the RF-negative group, whereas presence of IgM RF associated with increased inflammatory markers, especially ESR, dependent on the co-occurrence of ACPA. In other words, in early RA, RF and ACPA associate with different individual DAS28 components and in opposite directions.

Jul 3, 2023 | nature.com | Asmundur Oddsson |Patrick Sulem |Gardar Sveinbjornsson |Gudny A. Arnadottir |Valgerdur Steinthorsdottir |Gísli H. Halldórsson | +41 more

Author notesThese authors contributed equally: Asmundur Oddsson, Patrick Sulem. These authors jointly supervised this work: Kari Stefansson, Daniel F. Gudbjartsson. Authors and AffiliationsdeCODE genetics/Amgen, Inc., Reykjavik, IcelandAsmundur Oddsson, Patrick Sulem, Gardar Sveinbjornsson, Gudny A. Arnadottir, Valgerdur Steinthorsdottir, Gisli H. Halldorsson, Bjarni A. Atlason, Gudjon R. Oskarsson, Hannes Helgason, Hildigunnur Katrinardottir, Run Fridriksdottir, Brynjar O.

Jun 10, 2023 | nature.com | Asmundur Oddsson |Patrick Sulem |Gardar Sveinbjornsson |Gudny A. Arnadottir |Valgerdur Steinthorsdottir |Gísli H. Halldórsson | +41 more

Study samples and ethics declarationsFor Iceland, this study is based on whole-genome sequence data from the white blood cells of 49,708 Icelanders participating in various disease projects at deCODE Genetics14. In addition, a total of 155,250 Icelanders have been genotyped using Illumina SNP chips. All participating individuals who donated blood or buccal tissue samples, or their guardians, provided written informed consent.