Sebastian Duchêne

Oct 23, 2024 | nature.com | Adrianna M Turner |Ian R. Monk |Danielle Ingle |Stephanie Portelli |Torsten Seemann |Liam Sharkey | +7 more

AbstractMultidrug-resistant bacterial pathogens like vancomycin-resistant Enterococcus faecium (VREfm) are a critical threat to human health1. Daptomycin is a last-resort antibiotic for VREfm infections with a novel mode of action2, but for which resistance has been widely reported but is unexplained. Here we show that rifaximin, an unrelated antibiotic used prophylactically to prevent hepatic encephalopathy in patients with liver disease3, causes cross-resistance to daptomycin in VREfm.

Feb 17, 2024 | academic.oup.com | Sebastian Duchêne

Molecular sequence data from rapidly evolving organisms are often sampled at different points in time. Sampling times can then be used for molecular clock calibration. The root-to-tip (RTT) regression is an essential tool to assess the degree to which the data behave in a clock-like fashion. Here, we introduce Clockor2, a client-side web application for conducting RTT regression.

Dec 14, 2023 | science.org | Lijia Li |Frances Spragge |Sebastian Duchêne

PerspectiveEvolutionMicrobial genomes from ancient chickens uncover the drivers of pathogenicitySebastian Duchene [email protected] Info & AffiliationsAbstractAnalyzing the genomes of ancient pathogens has revolutionized the understanding of how they originate and spread. Most of this work has concentrated on human pathogens, but there is an increasing need to explain the origin of infectious disease in wildlife and domesticated animals (1). On page 1276 of this issue, Fiddaman et al.

Jul 15, 2023 | biorxiv.org | Leo Featherstone |Andrew Rambaut |Sebastian Duchêne |Wytamma Wirth

Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Jun 2, 2023 | academic.oup.com | Sebastian Duchêne

When you visit web sites, they may store or retrieve data in your web browser. This storage is often necessary for basic functionality of the web site or the storage may be used for the purposes of marketing, analytics, and personalization of the web site such as storing your preferences.