Seth Berger

Sep 10, 2024 | nature.com | Jens Chr. Hansen |Yuguang Xiong |Kristin G. Beaumont |Robert Sebra |James Gallo |Marc R. Birtwistle | +5 more

AbstractDrug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiomyocytes, using bulk transcriptomic profiles. We use singular value decomposition to identify drug-selective patterns across cell lines obtained from multiple healthy human subjects.

Jul 11, 2024 | nature.com | Yuyang Chen |Ruebena Dawes |Hyung Chul Kim |Sarah Stenton |Susan Walker |Jenny Lord | +42 more

AbstractAround 60% of individuals with neurodevelopmental disorders (NDD) remain undiagnosed after comprehensive genetic testing, primarily of protein-coding genes1. Large genome-sequenced cohorts are improving our ability to discover new diagnoses in the non-coding genome. Here we identify the non-coding RNA RNU4-2 as a syndromic NDD gene. RNU4-2 encodes the U4 small nuclear RNA (snRNA), which is a critical component of the U4/U6.U5 tri-snRNP complex of the major spliceosome2.

Feb 9, 2024 | biorxiv.org | Jessica Chong |Seth Berger |Samantha Baxter |Erica Smith

AbstractSince the first novel gene discovery for a Mendelian condition was made via exome sequencing (ES), the rapid increase in the number of genes known to underlie Mendelian conditions1 coupled with the adoption of exome (and more recently, genome) sequencing by diagnostic testing labs has changed the landscape of genomic testing for rare disease. Specifically, many individuals suspected to have a Mendelian condition are now routinely offered clinical ES.

Dec 5, 2023 | aspendailynews.com | Seth Berger

You voted: I'm fine, as I'm very fortunate to own my home I own, but I'm feeling the pinch on my mortgage with other inflation costs I rent and it's expensive, but it could be worse I'm seriously considering leaving the valley if something doesn't give

Sep 12, 2023 | thephiladelphiacitizen.org | Seth Berger

Do Something Next Presidential election: November 5, 2024.