Shahar Bracha

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Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons - Nature Microbiology

Jul 28, 2024 | nature.com | Shahar Bracha |Athena Economides |Daniel Walsh |Adriano Aguzzi |Lilach Sheiner

AbstractDelivering macromolecules across biological barriers such as the blood–brain barrier limits their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite that naturally travels from the human gut to the central nervous system (CNS), can deliver proteins to host cells. Here we engineered T.

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