Athena Economides

Aug 17, 2024 | biorxiv.org | Ehsan Dadgar-Kiani |Daniel Kirschenbaum |Athena Economides |Francesca Catto

AbstractA hallmark of Alzheimer's disease (AD) is the extracellular aggregation of toxic amyloid-beta (Aβ) peptides in form of plaques. Here, we identify netoglitazone, an antidiabetic compound previously tested in humans, as an Aβ aggregation antagonist. Netoglitazone improved cognition and reduced microglia activity in a mouse model of AD.

Jul 28, 2024 | nature.com | Shahar Bracha |Athena Economides |Daniel Walsh |Adriano Aguzzi |Lilach Sheiner

AbstractDelivering macromolecules across biological barriers such as the blood–brain barrier limits their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite that naturally travels from the human gut to the central nervous system (CNS), can deliver proteins to host cells. Here we engineered T.

Apr 17, 2024 | cell.com | Lucas Amoudruz |Athena Economides |Petros Koumoutsakos

Theory of oxygen transport to tissue. Crit. Rev. Biomed. Eng. 1989; 17: 257-321Di Caprio G. Stokes C. Schonbrun E. et al. Single-cell measurement of red blood cell oxygen affinity. Proc. Natl. Acad. Sci. USA. 2015; 112: 9984-9989Lim H.W.,G. Wortis M. Mukhopadhyay R. Red Blood Cell Shapes and Shape Transformations: Newtonian Mechanics of a Composite Membrane. Soft Matter. 2008; 4: 83-139Geekiyanage N.M. Balanant M.A. Gu Y. et al.

Mar 16, 2023 | cell.com | Athena Economides |Georgios Arampatzis |Lucas Amoudruz

Significance: Human erythrocytes, or red blood cells (RBCs) are the dominant constituents of blood and their dynamics is governed by the visco-elastic properties of their membrane. Despite its importance, today’s RBC membrane models are not able to predict blood flows without case specific adjustment of their parameters. Existing RBC models rely on the assumption of a stress-free state (SFS) of the cytoskeleton.