Siobhan K. Lock

Jan 17, 2025 | nature.com | Elise Koch |Nadine Staples Parker |Siobhan K. Lock |Oleksandr Frei |Anders M. Dale |Srdjan Djurovic | +1 more

AbstractWhile clozapine is the most effective antipsychotic drug, its use is limited due to hematological adverse effects involving the reduction of granulocyte counts with potential life-threatening agranulocytosis. It is not yet possible to predict or prevent the risk of agranulocytosis, and the mechanisms are unknown but likely related to clozapine metabolism. Genome-wide association studies (GWASs) of clozapine metabolism and clozapine-induced agranulocytosis have identified few genetic loci.