Elise Koch

Jan 17, 2025 | nature.com | Elise Koch |Nadine Staples Parker |Siobhan K. Lock |Oleksandr Frei |Anders M. Dale |Srdjan Djurovic | +1 more

AbstractWhile clozapine is the most effective antipsychotic drug, its use is limited due to hematological adverse effects involving the reduction of granulocyte counts with potential life-threatening agranulocytosis. It is not yet possible to predict or prevent the risk of agranulocytosis, and the mechanisms are unknown but likely related to clozapine metabolism. Genome-wide association studies (GWASs) of clozapine metabolism and clozapine-induced agranulocytosis have identified few genetic loci.

Sep 24, 2024 | medrxiv.org | Nadine Staples Parker |Elise Koch |Alexey Shadrin |Julian Führer

OAA has received speaker fees from Lundbeck, Janssen, Otsuka, and Sunovion and is a consultant to Cortechs.ai. and Precision Health. AMD is Founding Director, holds equity in CorTechs Labs, Inc. (DBA Cortechs.ai), and serves on its Board of Directors and the Scientific Advisory Board. He is an unpaid consultant for Oslo University Hospital. The terms of these arrangements have been reviewed and approved by the University of California, San Diego in accordance with its conflict-of-interest policies.

Jul 15, 2024 | medrxiv.org | Elise Koch |Tuuli Jürgenson |Gudmundur Einarsson |Brittany Mitchell

The authors have declared no competing interest. We would like to thank the research participants and employees of 23andMe, Inc. for making this work possible. This work was partly performed on the TSD (Tjeneste for Sensitive Data) facilities, owned by the University of Oslo, operated and developed by the TSD service group at the University of Oslo, IT-Department (USIT).

Apr 29, 2024 | biologicalpsychiatryjournal.com | Nadine Staples Parker |Piotr Jaholkowski |Guy Hindley |Elise Koch

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Jan 5, 2024 | nature.com | Elise Koch |Nils Eiel Steen |Olav B. Smeland |Srdjan Djurovic |Espen Molden

AbstractGenomic prediction of antipsychotic dose and polypharmacy has been difficult, mainly due to limited access to large cohorts with genetic and drug prescription data.