Soeren S Lienkamp

Oct 25, 2024 | nature.com | Fabiola Ceroni |Munevver B. Cicekdal |Nicolas Chassaing |Thomas Naert |Emma Kivuva |Soeren S Lienkamp | +5 more

AbstractAnophthalmia, microphthalmia and coloboma (AMC) comprise a spectrum of developmental eye disorders, accounting for approximately 20% of childhood visual impairment. While non-coding regulatory sequences are increasingly recognised as contributing to disease burden, characterising their impact on gene function and phenotype remains challenging. Furthermore, little is known of the nature and extent of their contribution to AMC phenotypes.

Mar 27, 2024 | nature.com | Nikita Vladimirov |Fabian Voigt |Sven Hildebrand |Dominik Groos |José María Mateos |Philipp Bethge | +5 more

AbstractIn 2015, we launched the mesoSPIM initiative, an open-source project for making light-sheet microscopy of large cleared tissues more accessible. Meanwhile, the demand for imaging larger samples at higher speed and resolution has increased, requiring major improvements in the capabilities of such microscopes.