Song Jiang

1 month ago | cell.com | Andrew W Daman |Anthony C. Antonelli |Gil Redelman-Sidi |Lucinda Paddock |Mythili Ketavarapu |Jin Gyu Cheong | +15 more

Keywordsbladder cancerBCGimmunotherapytumor immunitytrained immunityinnate immune memoryhematopoiesisepigeneticsGet full text accessLog in, subscribe or purchase for full access. References1. Dobosz, P. ∙ Dzieciątkowski, T. The intriguing history of cancer immunotherapyFront. Immunol. 2019; 10:29652. Heney, N.M.Natural history of superficial bladder cancer. Prognostic features and long-term disease courseUrol. Clin. North Am. 1992; 19:429-4333. Böhle, A. ∙ Jocham, D.

Oct 23, 2024 | nature.com | Yuxin Gu |Song Jiang |Ming Chen |Min-Xin Guan |Siqi Sun |Zhihong Liu | +1 more

AbstractWe present SpliceTransformer (SpTransformer), a deep-learning framework that predicts tissue-specific RNA splicing alterations linked to human diseases based on genomic sequence. SpTransformer outperforms all previous methods on splicing prediction. Application to approximately 1.3 million genetic variants in the ClinVar database reveals that splicing alterations account for 60% of intronic and synonymous pathogenic mutations, and occur at different frequencies across tissue types.