Siqi Sun

Nov 21, 2024 | nature.com | Tao Shen |Siqi Sun |Di Liu |Jiuming Wang |Jin Xiao |Sheng Wang | +2 more

AbstractAccurate prediction of RNA three-dimensional (3D) structures remains an unsolved challenge. Determining RNA 3D structures is crucial for understanding their functions and informing RNA-targeting drug development and synthetic biology design. The structural flexibility of RNA, which leads to the scarcity of experimentally determined data, complicates computational prediction efforts.

Oct 23, 2024 | nature.com | Yuxin Gu |Song Jiang |Ming Chen |Min-Xin Guan |Siqi Sun |Zhihong Liu | +1 more

AbstractWe present SpliceTransformer (SpTransformer), a deep-learning framework that predicts tissue-specific RNA splicing alterations linked to human diseases based on genomic sequence. SpTransformer outperforms all previous methods on splicing prediction. Application to approximately 1.3 million genetic variants in the ClinVar database reveals that splicing alterations account for 60% of intronic and synonymous pathogenic mutations, and occur at different frequencies across tissue types.

Mar 12, 2024 | opg.optica.org | Siqi Sun |Wenlong Wang |Yuechun Shi |Yang Xu

In this paper, a methane detection sensor based on direct absorption spectroscopy and the self-heating effect of lasers is proposed, which abandons the traditional method of relying on a thermoelectric cooler (TEC) to ensure stable gas concentration detection. The sensor can achieve stable concentration measurement in the temperature range of ${-}{10}^\circ$ to 40°C without the need for a TEC, which greatly simplifies the structure of the sensor and reduces the cost.

Dec 12, 2023 | onlinelibrary.wiley.com | Liya Ma |Engineering Beijing |Chen Li |Siqi Sun

CONFLICT OF INTEREST STATEMENT The authors declare no potential conflicts of interest. REFERENCES 1, , . A survey of graph-modification techniques for privacy-preserving on networks. Artif Intell Rev. 2017; 47: 341-366. 2, , . Privacy-preserving social media data publishing for personalized ranking-based recommendation. IEEE Trans Knowl Data Eng. 2019; 31: 507-520. 3, , , . Deep learning based recommender system: a survey and new perspectives. ACM Comput Surv. 2020; 52(1): 1-38.

Aug 28, 2023 | nature.com | Armin Dadras |Patricia Scholz |Siqi Sun |Cornelia Herrfurth |Maike MK Hansen |Gerhard H. Braus | +7 more

AbstractPlant terrestrialization brought forth the land plants (embryophytes). Embryophytes account for most of the biomass on land and evolved from streptophyte algae in a singular event. Recent advances have unravelled the first full genomes of the closest algal relatives of land plants; among the first such species was Mesotaenium endlicherianum.