Stavroula Kanoni

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Discovery and Systematic Characterization of Risk Variants and Genes for Coronary Artery Disease in Over a Million Participants

Aug 15, 2024 | digitalcommons.library.tmc.edu | Krishna G. Aragam |Tao Jiang |Anuj Goel |Stavroula Kanoni

The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly European ancestry. We detected 241 associations, including 30 new loci. Cross-ancestry meta-analysis with a Japanese GWAS yielded 38 additional new loci.
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation | Nature Genetics

May 29, 2023 | nature.com | David Adlam |Takiy-Eddine Berrandou |Adrien Georges |Christopher Nelson |Chris Finan |Siiri E. Iismaa | +21 more

AbstractSpontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD.

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