Steffen E. Petersen

2 months ago | nature.com | Danielle Rasooly |Claudia Giambartolomei |Gina M. Peloso |Maik Pietzner |Eric Farber-Eger |Lawrence Phillips | +4 more

AbstractHeart failure (HF) has limited therapeutic options. In this study, we differentiated the pathophysiological underpinnings of the HF subtypes—HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF)—and uncovered subtype-specific therapeutic strategies. We investigated the causal roles of the human proteome and transcriptome using Mendelian randomization on more than 420,000 participants from the Million Veteran Program (27,799 HFrEF and 27,579 HFpEF cases).

Nov 13, 2024 | nature.com | William Young |Nay Aung |Luis Lopes |Perry Elliott |Petros Syrris |Roberto Barriales-Villa | +3 more

AbstractHeart shape captures variation in cardiac structure beyond traditional phenotypes of mass and volume. Although observational studies have demonstrated associations with cardiometabolic risk factors and diseases, its genetic basis is less understood. We utilised cardiovascular magnetic resonance images from 45,683 UK Biobank participants to construct a heart shape atlas from bi-ventricular end-diastolic surface mesh models through principal component (PC) analysis.

Sep 19, 2023 | academic.oup.com | West Smithfield |Glen Road |Steffen E. Petersen

Since heart failure (HF) is associated with high morbidity, mortality, and health-care costs, timely diagnosis of subclinical cardiac dysfunction is an important aspect of cardiovascular (CV) preventive strategies.