Steve Horvath

3 weeks ago | nature.com | Chiara Herzog |Kejun Ying |Raghav Sehgal |Waylon J. Hastings |Alexander Tyshkovskiy |Sara Hägg | +19 more

On 1–2 November 2024, the annual Biomarkers of Aging conference welcomed academic and industry scientists, and partners from governmental and nongovernmental organizations, to Harvard Medical School in Boston, USA, to discuss new insights into measuring and monitoring human aging, with the aim of clinical translation. In this Meeting Report, we summarize the conference and offer potential future directions for the Biomarkers of Aging Consortium and the longevity science community at large.

Sep 15, 2024 | nature.com | Jesse R. Poganik |Daniel Belsky |Joe LaCroix |Alan Cohen |Steven R. Cummings |Luigi Ferrucci | +15 more

AbstractBiomarkers of aging (BOA) are quantitative parameters that predict biological age and ideally its changes in response to interventions. In recent years, many promising molecular and omic BOA have emerged with an enormous potential for translational geroscience and improving healthspan. However, clinical translation remains limited, in part due to the gap between preclinical research and the application of BOA in clinical research and other translational settings.

Feb 14, 2024 | nature.com | Chiara Herzog |Jesse R. Poganik |Kejun Ying |Daniel Belsky |Albert T. Higgins-Chen |Alan Cohen | +12 more

AbstractThe search for biomarkers that quantify biological aging (particularly ‘omic’-based biomarkers) has intensified in recent years. Such biomarkers could predict aging-related outcomes and could serve as surrogate endpoints for the evaluation of interventions promoting healthy aging and longevity. However, no consensus exists on how biomarkers of aging should be validated before their translation to the clinic.

Aug 7, 2023 | biorxiv.org | Steve Horvath |Kavita Singh |Ken Raj |Shraddha Khairnar

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