Tatsunori Miyata

Nov 6, 2024 | digitalcommons.library.tmc.edu | Xiaoqin Wu |Xiude Fan |Megan McMullen |Tatsunori Miyata

BACKGROUND AND AIMS: Mixed lineage kinase domain-like pseudokinase (MLKL), a key terminal effector of necroptosis, also plays a role in intracellular vesicle trafficking that is critical for regulating liver inflammation and injury in alcohol-associated liver disease (ALD). Although receptor interacting protein kinase 3 (Rip3)-/- mice are completely protected from ethanol-induced liver injury, Mlkl-/- mice are only partially protected.