Thales Papagiannakopoulos

2 weeks ago | nature.com | Alan Varghese |Rebecca Jones |Maria Gomez-Jenkins |Eileen White |Rui Wang |Drew Jones | +3 more

AbstractAround 40% of the US population and 1 in 6 individuals worldwide have obesity, with the incidence surging globally1,2. Various dietary interventions, including carbohydrate, fat and, more recently, amino acid restriction, have been explored to combat this epidemic3,4,5,6. Here we investigated the impact of removing individual amino acids on the weight profiles of mice.

Oct 16, 2024 | genesdev.cshlp.org | Michael Cross |Andrew Dillin |Thales Papagiannakopoulos

1,6 1Department of Pathology, New York University Grossman School of Medicine, New York, New York 10016, USA; 2Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, New York 10016, USA; 3Howard Hughes Medical Institute, University of California, Berkely, Berkeley, California 94720 USA; 4Department of Molecular and Cell Biology, University of California, Berkely, Berkeley, California 94720, USA; 5The Helen Wills Neuroscience Institute,...

Jul 10, 2024 | nature.com | Anjali Rao |Dalia Barkley |Igor Dolgalev |Thales Papagiannakopoulos |Andriy Marusyk |Timothée Lionnet | +3 more

AbstractAdvancements in precision oncology over the past decades have led to new therapeutic interventions, but the efficacy of such treatments is generally limited by an adaptive process that fosters drug resistance1. In addition to genetic mutations2, recent research has identified a role for non-genetic plasticity in transient drug tolerance3 and the acquisition of stable resistance4,5.