Tom R. Gaunt

2 weeks ago | nature.com | Christina Dardani |Hannah J. Jones |Evie Stergiakouli |Jakob Grove |Andrew McIntosh |Andrew Mcintosh | +3 more

AbstractImmune dysfunction is implicated in the aetiology of psychiatric, neurodevelopmental, and neurodegenerative conditions, but the issue of causality remains unclear impeding attempts to develop new interventions. Using genomic data on protein and gene expression across blood and brain, we assessed evidence of a potential causal role for 736 immune response-related biomarkers on 7 neuropsychiatric conditions by applying Mendelian randomization (MR) and genetic colocalisation analyses.

Aug 9, 2024 | medrxiv.org | Haotian Tang |Tom R. Gaunt |Venexia M Walker

TRG receives funding from Biogen and GSK for unrelated research. This work was supported by the UK Medical Research Council Integrative Epidemiology Unit (MC_UU_00032/03). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Apr 29, 2024 | medrxiv.org | Maria K Sobczyk |Tom R. Gaunt

T.R.G. receives funding from Biogen and GlaxoSmithKline for unrelated research. This work was funded by the UK Medical Research Council (MRC) as part of the MRC Integrative Epidemiology Unit (MC_UU_00032/03). This study was also supported by the NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol.

Apr 26, 2024 | medrxiv.org | Haotian Tang |Venexia M Walker |Tom R. Gaunt

The authors have declared no competing interest. This work was supported by the UK Medical Research Council Integrative Epidemiology Unit (MC_UU_00011/4 and MC_UU_00032/03). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Sep 26, 2023 | bmjopen.bmj.com | Maria K Sobczyk |Jie Zheng |George Smith |Tom R. Gaunt

ResultsIn total, we found 457 254 individual studies were registered with a unique ClinicalTrials.gov identifier. We filtered them using a number of steps to identify RCTs and facilitate comparison with MR (figure 2A). In our analysis, we identified 218 506 RCT studies (48% of the total).