Tomás Ripoll-Vera

Aug 15, 2024 | onlinelibrary.wiley.com | Pablo García-Pavía |Neal Lakdawala |Gianfranco Sinagra |Tomás Ripoll-Vera

Introduction Variants in the LMNA gene, which encodes the lamin A and C proteins, are the cause of several clinical syndromes including dilated cardiomyopathy (DCM).1 The pathogenesis of LMNA-related DCM is unclear, but preclinical studies have suggested that several processes are altered in cardiomyocytes, including activation of pro-inflammatory, apoptotic, fibrotic and mitogen-activated protein kinase pathways.2-4 LMNA-related DCM is a progressive and malignant disease characterized by...