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Oct 11, 2024 | 
nature.com | Gianfranco Sinagra
AbstractDilated cardiomyopathy (DCM) is a complex disease with multiple causes and various pathogenic mechanisms. Despite improvements in the prognosis of patients with DCM in the past decade, this condition remains a leading cause of heart failure and premature death. Conventional treatment for DCM is based on the foundational therapies for heart failure with reduced ejection fraction. However, increasingly, attention is being directed towards individualized treatments and precision medicine.
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Sep 18, 2024 | 
onlinelibrary.wiley.com | Maddalena Rossi |Complex Diseases |Enrico Fabris |Gianfranco Sinagra
Corresponding Author Gianfranco Sinagra Cardiothoracovascular Department, Center for Diagnosis and Treatment of Cardiomyopathies, Azienda Sanitaria Universitaria Giuliano-Isontina, University of Trieste, Trieste, Italy European Reference Network for Rare, Low-Prevalence, and Complex Diseases of the Heart (ERN GUARD-Heart) Corresponding author. Cardiothoracovascular Department, University of Trieste, Via Valdoni 7, 34129 Trieste, Italy.
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Aug 16, 2024 | 
jcp.bmj.com | Davide Radaelli |Joseph Westaby |Gherardo Finocchiaro |Gianfranco Sinagra
Sudden cardiac death with morphologically normal heart: always do toxicology Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
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Aug 15, 2024 | 
onlinelibrary.wiley.com | Pablo García-Pavía |Neal Lakdawala |Gianfranco Sinagra |Tomás Ripoll-Vera
Introduction Variants in the LMNA gene, which encodes the lamin A and C proteins, are the cause of several clinical syndromes including dilated cardiomyopathy (DCM).1 The pathogenesis of LMNA-related DCM is unclear, but preclinical studies have suggested that several processes are altered in cardiomyocytes, including activation of pro-inflammatory, apoptotic, fibrotic and mitogen-activated protein kinase pathways.2-4 LMNA-related DCM is a progressive and malignant disease characterized by...
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Mar 18, 2024 | 
jcp.bmj.com | Davide Radaelli |Joseph Westaby |Gherardo Finocchiaro |Gianfranco Sinagra
SUDDEN CARDIAC DEATHTOXICOLOGYCardiovascular DiseasesBackgroundSudden cardiac death (SCD) is defined as natural unexpected death occurring within <1 hour in witnessed cases and within <24 hours of last being seen alive in unwitnessed cases. To assess the cause of death, many guidelines have been produced1 and all toxicological investigation is essential. The term ‘sudden adult death syndrome’ (SADS) means an SCD where the heart is morphologically normal.
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Dec 10, 2023 | 
mdpi.com | Daniela PAvan |Daniela Pavan |Aldostefano Porcari |Gianfranco Sinagra |Riccardo Saro
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
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Aug 16, 2023 | 
onlinelibrary.wiley.com | Gianfranco Sinagra |Alberto Guarnaccia |Tang W-J |Xie B-K
The role of hypocapnia in acute heart failure (AHF) remains poorly understood. Tang and colleagues found that hypocapnia was associated with worse renal and cardiac function and a higher in-hospital, all-cause mortality in a cohort of patients with AHF.1 Respiratory rate was similar (approximately 20 breaths per minute; P = 0.857) for those with or without hypocapnia, suggesting that increased ventilation was not responsible for hypocapnia.
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Jun 23, 2023 | 
pubmed.ncbi.nlm.nih.gov | Gianfranco Sinagra |Marta Gigli |Matteo Dal Ferro |Dal Ferro M
Save citation to file Format: Add to My Bibliography Your saved search Name of saved search: Search terms: Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Create a file for external citation management software
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Jun 22, 2023 | 
onlinelibrary.wiley.com | Gianfranco Sinagra |Marta Gigli |Matteo Dal Ferro
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/ejhf.2943.
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Apr 26, 2023 | 
giornaledicardiologia.it | Angelo Avogaro |Alberto Corsini |Gianfranco Sinagra |Claudio Borghi
Senni M, Di Pasquale G, Calabrò P, Fioretto P, Trevisan R, Sciatti E, Borghi C, Sinagra G, Corsini A, Avogaro A. Incertezze nei fattori di rischio cardiovascolare: inibitori del cotrasportatore sodio-glucosio di tipo 2 per tutti i pazienti diabetici ad elevato rischio cardiovascolare e per tutti i pazienti con insufficienza renale indipendentemente dall’albuminuria? Agonisti del recettore del glucagon-like peptide-1 come arma contro l’obesità? G Ital Cardiol 2023;24(5):337-343.
