Tzu-Ting Chen

Aug 26, 2024 | nature.com | Kai Yuan |Antonio F Pardiñas |Mingrui Yu |Tzu-Ting Chen |Max Lam |Mark Daly | +5 more

AbstractGenome-wide association studies (GWAS) of human complex traits or diseases often implicate genetic loci that span hundreds or thousands of genetic variants, many of which have similar statistical significance. While statistical fine-mapping in individuals of European ancestry has made important discoveries, cross-population fine-mapping has the potential to improve power and resolution by capitalizing on the genomic diversity across ancestries.

Jun 26, 2024 | mdpi.com | Kuo-Tung Tang |Yu-Sin Chen |Mey-Fann Lee |Tzu-Ting Chen

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Jan 4, 2024 | nature.com | Tzu-Ting Chen |Jaeyoung Kim |Max Lam |Sang-Hyuk Jung |Soyeon Kim |Injeong Shim | +9 more

AbstractEducational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345).