Injeong Shim

Sep 30, 2024 | nature.com | Soyeon Kim |Jaeyoung Kim |Yeeun Ahn |Injeong Shim |Chamlee Cho |Patrick T. Ellinor | +2 more

AbstractMetabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic traits as risk factors. Although the genetics of individual MetS components have been investigated actively through large-scale genome-wide association studies, the conjoint genetic architecture has not been fully elucidated. Here, we performed the largest multivariate genome-wide association study of MetS in Europe (nobserved = 4,947,860) by leveraging genetic correlation between MetS components.

Jan 4, 2024 | nature.com | Tzu-Ting Chen |Jaeyoung Kim |Max Lam |Sang-Hyuk Jung |Soyeon Kim |Injeong Shim | +9 more

AbstractEducational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345).