Max Lam

Aug 26, 2024 | nature.com | Kai Yuan |Antonio F Pardiñas |Mingrui Yu |Tzu-Ting Chen |Max Lam |Mark Daly | +5 more

AbstractGenome-wide association studies (GWAS) of human complex traits or diseases often implicate genetic loci that span hundreds or thousands of genetic variants, many of which have similar statistical significance. While statistical fine-mapping in individuals of European ancestry has made important discoveries, cross-population fine-mapping has the potential to improve power and resolution by capitalizing on the genomic diversity across ancestries.

Feb 25, 2024 | nature.com | Max Lam |Jimmy Liu |Daniel F Levey |Joel Gelernter |Murray B. Stein |Ellen A. Tsai | +3 more

AbstractNearly two hundred common-variant depression risk loci have been identified by genome-wide association studies (GWAS). However, the impact of rare coding variants on depression remains poorly understood. Here, we present whole-exome sequencing analyses of depression with seven different definitions based on survey, questionnaire, and electronic health records in 320,356 UK Biobank participants.

Jan 4, 2024 | nature.com | Tzu-Ting Chen |Jaeyoung Kim |Max Lam |Sang-Hyuk Jung |Soyeon Kim |Injeong Shim | +9 more

AbstractEducational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345).

Nov 20, 2023 | nature.com | Daniel F Levey |Marco Galimberti |Joseph D. Deak |Dora Koller |Emma Johnson |Mahantesh Biradar | +12 more

AbstractAs recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities.

Jun 14, 2023 | jamanetwork.com | Andrew Grotzinger |Max Lam |Glen Oaks |Travis T. Mallard

Key PointsQuestion  Can genes be identified whose expression is associated with cross-disorder psychiatric risk along with existing drugs that target these genes? Findings  In this genetic association study, transcriptome-wide structural equation modeling was used to identify 466 genes associated with psychiatric genomic factors that index shared risk across subsets of disorders.