Umut Berkay Altıntaş

Nov 3, 2024 | nature.com | Umut Berkay Altıntaş |Claudia Giambartolomei |Geoffrey Nelson |Seth Goldman |Karen Adelman |Matthew Freedman

AbstractAndrogen receptor (AR)-mediated transcription plays a critical role in development and prostate cancer growth. AR drives gene expression by binding to thousands of cis-regulatory elements (CRE) that loop to hundreds of target promoters. With multiple CREs interacting with a single promoter, it remains unclear how individual AR bound CREs contribute to gene expression.