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Jan 23, 2025 | 
link.springer.com | Université de Tours
AbstractTrichogerminoma (TG) is a rare adnexal tumor with hair follicle differentiation with less than 50 cases reported in the literature. In 2022, by investigating the genetic profile of 21 cases, our group identified recurrent rearrangements of the GRHL1/2/3 genes in this tumor entity, suggesting such alteration as the main oncogenic driver in TG. Up to now, only one TG case of malignant transformation has been reported.
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Aug 28, 2024 | 
onlinelibrary.wiley.com | Pierre Nizet |Université de Tours |Adrien Evin |Nantes Université
DATA AVAILABILITY STATEMENT The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request.
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Jun 14, 2024 | 
academic.oup.com | Université de Tours
By providing innate immune modulatory stimuli, the early life immune system can be enhanced to increase resistance to infections. Activation of innate cell surface receptors called pattern recognition receptors (PRRs) by TLR ligands is one promising approach that can help to control infections as described for listeriosis and cryptosporidiosis. In this study, the effect of TLR2/TLR1 and TLR2/TLR6 agonists was compared when injected into neonatal mice.
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May 4, 2024 | 
academic.oup.com | Université de Tours
The use of psilocybin to treat alcohol use disorder is very promising, but the mechanisms of action remain poorly understood. We combined behavioral, pharmacological and gene expression analyses to decipher the mechanisms of action of psilocybin, for the first time injected into the brain. Male Long Evans rats underwent chronic operant ethanol self-administration before testing the effect of intraperitoneal psilocybin or directly within the nucleus accumbens core or the ventral tegmental area.
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Mar 18, 2024 | 
link.springer.com | Université de Tours
AbstractAmyotrophic lateral sclerosis (ALS) is a severe motor neuron disorder. Diagnosis is challenging due to its clinical heterogeneity and the absence of definitive diagnostic tools, leading to delays averaging between 9.1 and 27 months. In vivo corneal confocal microscopy, assessing the sub-basal nerve plexus of the cornea, has been proposed as a potential biomarker for ALS.
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Dec 20, 2023 | 
journals.ltn.lodz.pl | Fabrice Leduc |Université de Tours
Abstract Background: The legislator employs various vague and undefined concepts, referred to as standards (e.g., fault, force majeure, reasonable belief, latent defects, foreseeability of harm, substantial imbalance, etc.). These standards consist of assessing the behaviour or situation by comparing it with a reference model that allows for determining their correctness.
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Jul 18, 2023 | 
bmcpublichealth.biomedcentral.com | De Stefano |Université de Bordeaux |Université de Tours |Université Paris Saclay
The results of the present study highlight the impact of structural social determinants, such as parents’ socio-demographic characteristics, housing and living conditions, on children’s psychological distress during the period of the first national lockdown. With regard to children’s socio-demographic characteristics, being a female was associated with moderate psychological distress.
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Jun 22, 2023 | 
ccforum.biomedcentral.com | CHRU Tours |Médecine Intensive Réanimation |Université de Tours
Severe ABI refers to a sudden event that results in brain damage and reduced perfusion leading to reduced alertness. ABI is heterogeneous and covers different subtypes, notably traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial bleeding and hypoxic ischemic brain injury.
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Jun 7, 2023 | 
link.aps.org | Université de Tours |Far Eastern Federal
Abstract We present the results of first-principle numerical simulations of Euclidean SU(3) Yang-Mills plasma rotating with a high imaginary angular frequency. The rigid Euclidean rotation is introduced via “rotwisted” boundary conditions along the imaginary-time direction. The Polyakov loop in the corotating Euclidean reference frame shows the emergence of a spatially inhomogeneous confining-deconfining phase through a broad crossover transition.
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Mar 16, 2023 | 
link.aps.org | Université de Tours |Far Eastern Federal
Abstract Using first-principle lattice simulations, we demonstrate that in the background of a strong magnetic field (around 1020T), the electroweak sector of the vacuum experiences two consecutive crossover transitions associated with dramatic changes in the zero-temperature dynamics of the vector W bosons and the scalar Higgs particles, respectively.
