Valeria Venturini

May 14, 2024 | biorxiv.org | Manuel Gómez-González |Céline Labouesse |Valeria Venturini |Srivatsava Viswanadha

AbstractThe first step in the differentiation of mouse embryonic stem cells (mESCs) is the loss of naïve pluripotency. This step involves a major reshaping of cells from a rounded to a spread, adhesive phenotype. Whereas such reshaping is typically associated with increased force transmission to the extracellular matrix (ECM), the magnitude and role of cell-matrix forces in the loss of naïve pluripotency is unknown.

Apr 17, 2024 | nature.com | Valeria Venturini |Adrià Cañellas-Socias |Camille Stephan-Otto Attolini |Catherine Xu |Giorgio Stassi |Pere Roca-Cusachs | +4 more

AbstractColorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical properties, and how these properties might contribute to metastasis is poorly understood.

Dec 5, 2023 | biorxiv.org | Valeria Venturini |Adrià Cañellas-Socias |Sefora Conti |Carme Cortina

AbstractColorectal cancer tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical properties, and how these properties might contribute to metastasis is unknown.