Pere Roca-Cusachs

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N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity - Nature Communications

Oct 11, 2024 | nature.com | Eva Barcelona-Estaje |Aleixandre Rodrigo-Navarro |Matthew Dalby |Pere Roca-Cusachs |Marco Cantini

AbstractMesenchymal stem cells (MSCs) interact with their surroundings via integrins, which link to the actin cytoskeleton and translate physical cues into biochemical signals through mechanotransduction. N-cadherins enable cell-cell communication and are also linked to the cytoskeleton. This crosstalk between integrins and cadherins modulates MSC mechanotransduction and fate.
Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells - Nature Communications

Apr 17, 2024 | nature.com | Valeria Venturini |Adrià Cañellas-Socias |Camille Stephan-Otto Attolini |Catherine Xu |Giorgio Stassi |Pere Roca-Cusachs | +4 more

AbstractColorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical properties, and how these properties might contribute to metastasis is poorly understood.

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