Wesley L. Cai

Aug 21, 2024 | biorxiv.org | Jocelyn Chen |Peng Xu |Wesley L. Cai |Huacui Chen

AbstractMetastasis is the major cause of cancer-related deaths. Emerging evidence has shown that epigenetic regulation plays a fundamental role in cancer metastasis. To better understand the epigenetic regulation of metastasis, we conducted an in vivo shRNA screen for vulnerabilities of brain metastasis and identified N-acetyltransferase 10 (NAT10) as a driver of brain metastasis.

Jun 13, 2023 | journals.plos.org | Madison S Strine |Wesley L. Cai |Jin Wei

Loading metrics Open Access Peer-reviewedResearch Article AbstractIdentifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding of Coronavirus Disease 2019 (COVID-19). We previously performed a genome-wide CRISPR/Cas9 screen to identify proviral host factors for highly pathogenic human coronaviruses.