Wolfgang Wurst

Dec 4, 2024 | nature.com | Tim Hasenbein |Sarah Hoelzl |Zachary Smith |Chiara Gerhardinger |Oana Amarie |Lore Becker | +9 more

AbstractThe lncRNA Crossfirre was identified as an imprinted X-linked gene, and is transcribed antisense to the trans-acting lncRNA Firre. The Firre locus forms an inactive-X-specific interaction with Dxz4, both loci providing the platform for the largest conserved chromatin structures. Here, we characterize the epigenetic profile of these loci, revealing them as the most female-specific accessible regions genome-wide.

Nov 10, 2024 | nature.com | Jianping Wu |Georg Kislinger |Benedikt Wefers |Wolfgang Wurst |Christian Behrends |Martina Schifferer | +2 more

AbstractOligodendrocytes extend numerous cellular processes that wrap multiple times around axons to generate lipid-rich myelin sheaths. Myelin biogenesis requires an enormously productive biosynthetic machinery for generating and delivering these large amounts of newly synthesized lipids. Yet, a complete understanding of this process remains elusive.