Xia Shen

Oct 7, 2024 | onlinelibrary.wiley.com | Qing Tan |Yong He |Xia Shen |Lin Sun

CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description jmv29945-sup-0001-JMV_24_22746_Supplementary_Figures_Highlighted.docx4.2 MB Supporting information. jmv29945-sup-0002-JMV_24_22746_Supplementary_Table_S1.docx16.9 KB Supporting information. jmv29945-sup-0003-JMV_24_22746_Supplementary_Table_S2.docx17.4 KB Supporting information.

Apr 28, 2024 | nature.com | Karl Smith-Byrne |Marios Dimitriou |Mine Koprulu |Maik Pietzner |Claudia Langenberg |Joshua Atkins | +10 more

AbstractCirculating proteins can reveal key pathways to cancer and identify therapeutic targets for cancer prevention. We investigate 2,074 circulating proteins and risk of nine common cancers (bladder, breast, endometrium, head and neck, lung, ovary, pancreas, kidney, and malignant non-melanoma) using cis protein Mendelian randomisation and colocalization. We conduct additional analyses to identify adverse side-effects of altering risk proteins and map cancer risk proteins to drug targets.

May 30, 2023 | frontiersin.org | Shanghai Jiao Tong |Kristy A Nielson |Vinod Kumar |Xia Shen

IntroductionUnder normal physiological conditions, the human brain requires 20% of the cardiac output and consumes 20% of the body’s oxygen and glucose (Iadecola, 2013). Since the brain stores little energy, it obtains energy through its blood supply, which must pass through the blood–brain barrier (BBB; Iadecola, 2017). The BBB is an important structure that maintains the homeostasis of the brain’s internal environment and protects the physiological functions of the central nervous system.