Xiaxi Dong

Oct 29, 2024 | science.org | Vincent Rondeau |Zhigang Li |Amy Baek |Xiaxi Dong

Editor’s summaryIn contrast to the neonatal mammalian heart, in which cardiomyocyte proliferation can enable complete repair, cardiomyocytes in the adult mammalian heart must be induced to reenter the cell cycle to achieve regeneration. Increases in purine availability are required to support enhanced DNA and RNA synthesis during proliferation, leading Li et al. to investigate how cardiac regeneration is affected by Adssl1, a critical enzyme in de novo purine synthesis.