
Yan Sun
Articles
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4 weeks ago |
dx.doi.org | Yipeng Zang |Haitao Li |Yan Sun |Lei Tang
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2 months ago |
nature.com | Danielle Rasooly |Claudia Giambartolomei |Gina M. Peloso |Maik Pietzner |Eric Farber-Eger |Lawrence Phillips | +4 more
AbstractHeart failure (HF) has limited therapeutic options. In this study, we differentiated the pathophysiological underpinnings of the HF subtypes—HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF)—and uncovered subtype-specific therapeutic strategies. We investigated the causal roles of the human proteome and transcriptome using Mendelian randomization on more than 420,000 participants from the Million Veteran Program (27,799 HFrEF and 27,579 HFpEF cases).
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2 months ago |
arxiv.org | Yan Sun |Mark Nixon
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Jan 16, 2025 |
nature.com | Han Zhao |Jin Liu |Xuebiao Yao |Wei Xie |Yan Sun |Keliang Wu | +4 more
AbstractUp to an estimated 10% of women experience miscarriage in their lifetimes. Embryonic aneuploidy is a leading cause for miscarriage, infertility and congenital defects. Here we identify variants of ELL3, a gene encoding a transcription elongation factor, in couples who experienced consecutive early miscarriages due to embryonic aneuploidy. Maternal ELL3 knockout leads to mouse oocyte aneuploidy, subfertility and miscellaneous embryonic defects.
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Jan 8, 2025 |
pubs.rsc.org | Jingchun Wang |Yan Sun |Yan Cui |Huibin Qiu
Tailored on-surface fabrication of mesoporous metallic composites by direct pyrolysis of metal ion-accumulated micellar films for enhanced electrocatalytic water splitting Amphiphilic block copolymers have been ubiquitously utilized as templates for the diverse fabrication of mesoporous films with tunable structure and constitution.
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