Lei Tang

Oct 9, 2024 | nature.com | Lei Tang

For Nature Methods’ 20th anniversary, our current and past editors reminisce about their favorite papers, initiatives and projects at the journal. I joined in the journal in 2018 with a background in enzymatically based de novo DNA synthesis. One of the earliest papers I published introduced the SABER method, which leverages DNA concatemers to enhance FISH signal.

Oct 9, 2024 | nature.com | Lei Tang

Despite the development of various tools, characterizing endogenous biomolecular condensation, often driven by multivalent interactions among proteins and RNAs, remains a challenge. “We definitely need new tools, especially ways of directly probing material states, viscoelasticity etc., and mapping complex phase behavior in condensates. I also think that while native condensates are cool, synthetic engineered ones could be even cooler!” says Clifford Brangwynne of Princeton University.

Oct 9, 2024 | dx.doi.org | Xin Huang |Lei Tang |Chuan Ma |Guangchuan Tang

Bioenergy, Biofuels, and BiorefineryOctober 9, 2024 * Xin Huang Key Laboratory of Low-Grade Energy Utilization Technologies and Systems of Ministry of Education, School of Energy and Power Engineering, Chongqing University, Chongqing 400044, China *E-mail: [email protected] Guangchuan Tang Key Laboratory of Low-Grade Energy Utilization Technologies and Systems of Ministry of Education, School of Energy and Power Engineering, Chongqing University, Chongqing 400044, China Lei Tang Key...

Sep 19, 2024 | sciencedirect.com | Shakti Singh |Bal Chandra Yadav |Lei Tang |Jin Zhang

Wearable electronic sensing devices can be designed to detect various physiological responses and microscopic changes in the skin in vivo by converting mechanical strain into electrical signals [1]. The use of these sensors enables real-time monitoring, which can result in the early detection and treatment of health issues or diseases [2], [3]. Advancements in wearable sensors have not only revolutionized human healthcare but also had a significant impact on animal research.

Aug 9, 2024 | nature.com | Lei Tang

The chemical modifications on DNA and histone proteins provide additional regulatory control over gene expression. Epigenome editing to these epigenetic marks, such as DNA methylation, holds great promise for studying the functions of specific modifications and developing therapeutic strategies to silence or activate gene expression without altering the DNA sequence. Previous epigenetic tools such as CRISPRoff are effective in silencing gene expression.