Lei Tang

Shanghai Shi

Senior Editor at Nature Methods

Scientific editor at Nature Methods. All views are my own.

Articles

Tracking gene transfer using RNA tools - Nature Methods

3 weeks ago | nature.com | Lei Tang

Gene transfer has a central role in shaping microbial community, and influences cell–cell interactions, niche adaptation and the spread of antibiotic resistance genes. Accurately tracking gene transfer events across species in real-world environmental conditions is essential to understanding how resistance genes propagate and persist in complex microbial communities.
Integrated Simulation and Optimization of Reservoir‐Wellbore‐Surface Systems in Ultrahigh Water Cut Oil Fields

1 month ago | scijournals.onlinelibrary.wiley.com | Hongmin Yu |Peng Wang |Youqi Wang |Lei Tang

1 Introduction Ultrahigh water-cut oil reservoirs present significant challenges, including high water cut levels exceeding 95%, severe inefficient water cycling due to dominant flow paths, variations in reservoir properties such as porosity and permeability, and dispersed distribution of remaining oil [1-3]. These factors complicate reservoir management and recovery.
CRISPR–Csm guided RNA imaging - Nature Methods

1 month ago | nature.com | Lei Tang

CRISPR RNA-targeting tools enable the visualization of native individual transcripts in living cells.
Controlling the Activity and Selectivity of Cu Catalysts toward Industrially Relevant Ethanol Electrosynthesis via High-Index Step Density Engineering

2 months ago | dx.doi.org | Yipeng Zang |Haitao Li |Yan Sun |Lei Tang
Tackling in vivo screening complexity - Nature Methods

Feb 11, 2025 | nature.com | Lei Tang

In vitro CRISPR screens have transformed high-throughput functional genomics, enabling the systematic study of gene functions in cell culture. However, these methods have yet to make the same mark for screening in vivo. To address this gap, the Ulrich Elling lab from Institute of Molecular Biotechnology of the Austrian Academy of Sciences (now at Viverita Discovery in Vienna) is working to bring CRISPR screening into in vivo biology.
Learning regulatory grammar - Nature Methods

Jan 13, 2025 | nature.com | Lei Tang

Ryan Tewhey from the Jackson Laboratory uses the concept of ‘regulatory grammar’ to describe the intricate logic linking DNA sequence to CRE function.
More dimensions of the 3D genome - Nature Methods

Dec 6, 2024 | nature.com | Lei Tang

Advances aim to capture comprehensive, dynamic genome structures in living cells.
Holistic views of individual cells - Nature Methods

Oct 9, 2024 | nature.com | Lei Tang

For Nature Methods’ 20th anniversary, our current and past editors reminisce about their favorite papers, initiatives and projects at the journal. I joined in the journal in 2018 with a background in enzymatically based de novo DNA synthesis. One of the earliest papers I published introduced the SABER method, which leverages DNA concatemers to enhance FISH signal.
Synthetic condensates probe chromatin viscoelasticity - Nature Methods

Oct 9, 2024 | nature.com | Lei Tang

Despite the development of various tools, characterizing endogenous biomolecular condensation, often driven by multivalent interactions among proteins and RNAs, remains a challenge. “We definitely need new tools, especially ways of directly probing material states, viscoelasticity etc., and mapping complex phase behavior in condensates. I also think that while native condensates are cool, synthetic engineered ones could be even cooler!” says Clifford Brangwynne of Princeton University.
Performances and Mechanisms of Dehydration of Levoglucosan to Levoglucosenone over Cesium Heterpolyacid Salts

Oct 9, 2024 | dx.doi.org | Xin Huang |Lei Tang |Chuan Ma |Guangchuan Tang

Bioenergy, Biofuels, and BiorefineryOctober 9, 2024 * Xin Huang Key Laboratory of Low-Grade Energy Utilization Technologies and Systems of Ministry of Education, School of Energy and Power Engineering, Chongqing University, Chongqing 400044, China *E-mail: [email protected] Guangchuan Tang Key Laboratory of Low-Grade Energy Utilization Technologies and Systems of Ministry of Education, School of Energy and Power Engineering, Chongqing University, Chongqing 400044, China Lei Tang Key...

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Lei Tang @DrLeiTang

11 May 25

We are recruiting！

Nature Methods @naturemethods

Exciting news...Nature Methods is hiring a new editor! This exciting and dynamic role will be shared with the Nature Research Cross-Journal Editorial Team. Apply here by June 1! https://t.co/5v3dNNKH1q https://t.co/cz1L36RX3k

Lei Tang @DrLeiTang

20 Feb 25

RT @SpringerNature: Tomorrow is #LoveYourPetDay, a very important day for us at Springer Nature. We love to celebrate the wonderful pets th…

Lei Tang @DrLeiTang

14 Feb 25

Feb RH on in vivo CRISPR screening!

Nature Methods @naturemethods

Research Highlight by @DrLeiTang: the @EllingUlrich lab introduces CRISPR-StAR to bring CRISPR screening into in vivo biology. Paper: https://t.co/ydB0Hb7iQS Highlight: https://t.co/6CMuayjyVA

Lei Tang

Articles

Tracking gene transfer using RNA tools - Nature Methods

Integrated Simulation and Optimization of Reservoir‐Wellbore‐Surface Systems in Ultrahigh Water Cut Oil Fields

CRISPR–Csm guided RNA imaging - Nature Methods

Controlling the Activity and Selectivity of Cu Catalysts toward Industrially Relevant Ethanol Electrosynthesis via High-Index Step Density Engineering

Tackling in vivo screening complexity - Nature Methods

Learning regulatory grammar - Nature Methods

More dimensions of the 3D genome - Nature Methods

Holistic views of individual cells - Nature Methods

Synthetic condensates probe chromatin viscoelasticity - Nature Methods

Performances and Mechanisms of Dehydration of Levoglucosan to Levoglucosenone over Cesium Heterpolyacid Salts

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