Yanhong Shi

Nov 28, 2024 | cell.com | Guoqiang Sun |Cheng Wang |Randall C Mazzarino |Hayk Davtyan |Mathew Blurton-Jones |Francisco Lopera | +3 more

Keywordsinduced pluripotent stem cellsiPSCsAPOE Christchurchlipid dropletlipid peroxidationferroptosisphagocytosismicrogliabrain organoidsTaupresenilinresilienceResearch topic(s)CP: NeuroscienceIntroductionAlzheimer’s disease (AD) is a devastating neurodegenerative disease.1,2 However, there is little progress toward therapeutic development for AD.

Oct 23, 2024 | cell.com | Yue Qin |Qi Cui |Guihua Sun |Jianfei Chao |Cheng Wang |Xianwei Chen | +12 more

Apr 25, 2024 | nature.com | Yanhong Shi

AbstractThe induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs have the capacity for an almost unlimited expansion, are amenable to genetic engineering, and can be differentiated into most somatic cell types. iPSCs have been widely applied to model human development and diseases, perform drug screening, and develop cell therapies.

Nov 21, 2023 | frontiersin.org | Abed AlFatah Mansour |Yanhong Shi |Jeffrey Jones

IntroductionAstrocytes are abundant cells in the central nervous system (CNS) that serve myriad functions in maintaining the general homeostasis of neurons during healthy development, maturation, and aging.