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1 month ago | 
nature.com | Shuangsang Fang |Mengyang Xu |Zhiyuan Yuan |Yao Li |Vladimir Kovacevic |Lidong Guo | +10 more
AbstractUnderstanding complex biological systems requires tracing cellular dynamic changes across conditions, time, and space. However, integrating multi-sample data in a unified way to explore cellular heterogeneity remains challenging. Here, we present Stereopy, a flexible framework for modeling and dissecting comparative and spatiotemporal patterns in multi-sample spatial transcriptomics with interactive data visualization.
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Mar 6, 2025 | 
mdpi.com | Yuzhou Zhang |Luoyang Wang |Qing Zhang |Yao Li
1. IntroductionUrban flooding has become a global challenge [1,2,3], frequently causing severe damage to infrastructure and the economy, and threats to urban safety and sustainability [4]. Rapid urbanization has led to large-scale impervious surface development, significantly altering the natural hydrological cycle, reducing infiltration capacity, and intensifying stormwater runoff [5].
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Dec 27, 2024 | 
mdpi.com | Yao Li
1. IntroductionBabbitt alloys are one of the widely used materials in plain bearings and are frequently used in components such as turbines, engines and pump body parts [1]. At present, the most widely used industrial babbitt alloys are tin-based and lead-based.
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Oct 6, 2024 | 
medrxiv.org | Yao Li |Tingting Li |Fei Xiao |Lijun Wang
The authors have declared no competing interest. This work was supported by National Key R&D Program of China (2022YFC2504500 to Yan Kang) andby National Natural Science Foundation of China (82172142 to Fei Xiao, 82272199 to Xuelian Liao). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Jul 23, 2024 | 
mdpi.com | Yi Cui |Yao Li |Jayson R. Miedema |Sharon N. Edmiston
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jul 18, 2024 | 
bmccancer.biomedcentral.com | Gujie Wu |Jun Liu |Haochun Shi |Binyang Pan |Xiaolin Wang |Yao Li | +3 more
ReferencesSung H, Ferlay J, Siegel RL, et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. https://doi.org/10.3322/caac.21660. Article CAS PubMed Google Scholar Choi J, Tocco B, Smith A, Ahmad S, Josephides E, Bille A. Multimodality Treatment and salvage surgery for the treatment of Lung Cancer. Cancers (Basel). 2023;15(14):3586. https://doi.org/10.3390/cancers15143586.
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Jun 14, 2024 | 
mdpi.com | Tangjun Xu |Wenwen Zhang |Yao Li |Jiachen Wang
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
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May 27, 2024 | 
nature.com | Yao Li |Yunji Feng |Fanshuo Qiu |Chengpu Yu
Key nodes are similar to important hubs in a network structure, which can directly determine the robustness and stability of the network. By effectively identifying and protecting these critical nodes, the robustness of the network can be improved, making it more resistant to external interference and attacks. There are various topology analysis methods for a given network, but key node identification methods often focus on either local attributes or global attributes. Designing an algorithm that combines both attributes can improve the accuracy of key node identification. In this paper, the constraint coefficient of a weakly connected network is calculated based on the Salton indicator, and a hierarchical tenacity global coefficient is obtained by an improved K-Shell decomposition method. Then, a hierarchical comprehensive key node identification algorithm is proposed which can comprehensively indicate the local and global attributes of the network nodes. Experimental results on real network datasets show that the proposed algorithm outperforms the other classic algorithms in terms of connectivity, average remaining edges, sensitivity and monotonicity.
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Apr 23, 2024 | 
preprints.org | Ping Tian |Yao Li |Jia Zhang |Jun Zhang
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 22 April 2024 / Approved: 23 April 2024 / Online: 24 April 2024 (03:41:32 CEST) Tian, P.R.; Li, Y.L.; Zhang, J.D.; Zhang, J.; Wang, K.C.; Quan, K.X. Response of Photosynthetic Capacity to Climate Warming and Its Variation among 11 Provenances of Dahurian Larch (Larix gmelinii). Preprints 2024, 2024041485.
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Mar 20, 2024 | 
journals.plos.org | Lu Zhang |Yao Li |Jens H. Kuhn |PLOS Pathogens
Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Zhang L, Li Y, Kuhn JH, Zhang K, Song Q, Liu F (2024) Polyubiquitylated rice stripe virus NS3 translocates to the nucleus to promote cytosolic virus replication via miRNA-induced fibrillin 2 upregulation. PLoS Pathog 20(3): e1012112.
