Martin Dichgans

Featured in: Favicon

nature.com Favicon

science.org Favicon

cell.com

thelancet.com Favicon

neurology.org

Articles

DNA-sensing inflammasomes cause recurrent atherosclerotic stroke - Nature

Aug 7, 2024 | nature.com | Jiayu Cao |Stefan Roth |Anna Kopczak |Yaw Asare |Marios K. Georgakis |Jack Green | +12 more

AbstractThe risk of early recurrent events after stroke remains high despite currently established secondary prevention strategies1. Risk is particularly high in patients with atherosclerosis, with more than 10% of patients experiencing early recurrent events1,2. However, despite the enormous medical burden of this clinical phenomenon, the underlying mechanisms leading to increased vascular risk and recurrent stroke are largely unknown.
Breaking barriers: noncanonical inflammasome executes blood–brain barrier disruption - Signal Transduction and Targeted Therapy

Aug 6, 2024 | nature.com | Martin Dichgans |Yaw Asare

In a landmark study recently published in Nature,1 Wei and colleagues demonstrate that the activation of GSDMD by the cytosolic lipopolysaccharide (LPS) sensor caspase-11 triggers blood–brain barrier (BBB) breakdown upon LPS challenge independent of TLR4-induced cytokine release. Their work identifies the noncanonical inflammasome and GSDMD pore formation as a potential target for treating central nervous system (CNS) disorders associated with inflammatory BBB dysfunction.
Tipping points in neurodegeneration

Jun 28, 2023 | cell.com | Johannes Levin |Martin Dichgans

Cookie Preference CenterWe use cookies which are necessary to make our site work. We may also use additional cookies to analyse, improve and personalise our content and your digital experience. For more information, see our Cookie Policy and the list of Google Ad-Tech Vendors. You may choose not to allow some types of cookies. However, blocking some types may impact your experience of our site and the services we are able to offer.
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores - Nature Communications

Feb 9, 2023 | nature.com | Itziar de Rojas |Najada Stringa |Anna Zettergren |Rebecca Sims |Céline Bellenguez |Miguel Calero | +79 more

Author notesThese authors contributed equally: Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris E. Jansen. These authors jointly supervised this work: Jordi Clarimón, Mercè Boada, Wiesje M. van der Flier, Alfredo Ramirez, Jean-Charles Lambert, Sven J. van der Lee, Agustín Ruiz.