Martin Dichgans

2 months ago | cell.com | Kami Pekayvaz |Badr Kilani |Markus Joppich |Luke Eivers |Sophia Brambs |Viktoria Knottenberg | +31 more

Keywords immunothrombosis thrombosis immune landscape neutrophils monocytes innate immunity single-cell multi-omics immunothrombolysis thrombus resolution immunothrombotic dysregulation thromboinflammation stroke immune-cell plasticity organ ischemia Introduction Thrombosis and thromboembolism are a major global cause of morbidity and mortality by leading to myocardial infarction, stroke, and venous thromboembolism.1,2 Simultaneously, anti-thrombotic therapies carry a relevant risk of...

Aug 7, 2024 | nature.com | Jiayu Cao |Stefan Roth |Anna Kopczak |Yaw Asare |Marios K. Georgakis |Jack Green | +12 more

AbstractThe risk of early recurrent events after stroke remains high despite currently established secondary prevention strategies1. Risk is particularly high in patients with atherosclerosis, with more than 10% of patients experiencing early recurrent events1,2. However, despite the enormous medical burden of this clinical phenomenon, the underlying mechanisms leading to increased vascular risk and recurrent stroke are largely unknown.

Aug 6, 2024 | nature.com | Martin Dichgans |Yaw Asare

In a landmark study recently published in Nature,1 Wei and colleagues demonstrate that the activation of GSDMD by the cytosolic lipopolysaccharide (LPS) sensor caspase-11 triggers blood–brain barrier (BBB) breakdown upon LPS challenge independent of TLR4-induced cytokine release. Their work identifies the noncanonical inflammasome and GSDMD pore formation as a potential target for treating central nervous system (CNS) disorders associated with inflammatory BBB dysfunction.

Jun 28, 2023 | cell.com | Johannes Levin |Martin Dichgans

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