Yi Xia

Oct 14, 2024 | mdpi.com | Zhi Chen |Yi Xia

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Jul 2, 2024 | cell.com | Jelena Kolic |Wenqing Sun |Haoning Cen |Jessica D. Ewald |Jason C. Rogalski |Shugo Sasaki | +14 more

Keywordshuman isletstype 2 diabetesstem cell-derived isletsinsulin secretionproteomicsmacronutrientsRNA-seqIntroductionInsulin is released by pancreatic islet beta cells in response to nutrient stimuli to maintain energy homeostasis. The major driver of insulin secretion is glucose. However, proteins and fats may also modulate insulin release, and the effects of non-carbohydrate nutrients on insulin secretion remain underexplored.

Nov 30, 2023 | link.aps.org | Zhi Li |Yi Xia |Materials Engineering |Chris M Wolverton

Accurate and reliable first-principles simulations of lattice thermal conductivity (κL) of highly anharmonic crystals have long been challenging in condensed matter and materials physics. With recent theoretical advances, the calculation of κL has evolved into a sophisticated process requiring the consideration of higher levels of refinements, such as high-order phonon-phonon scattering, anharmonic phonon renormalization, and heat transport beyond the phonon gas picture.

Oct 31, 2023 | cell.com | Yi Xia |Jeffrey Lin |Ken Chu |Jenny Yang

These cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work. These cookies do not store any personally identifiable information.

Oct 10, 2023 | biorxiv.org | Anni Zhang |Yi Xia |Jeffrey Lin |Ken Chu

AbstractThe rising pancreatic cancer incidence due to obesity and type 2 diabetes is closely tied to hyperinsulinemia, an independent cancer risk factor. Previous studies demonstrated reducing insulin production suppressed pancreatic intraepithelial neoplasia (PanIN) pre-cancerous lesions in Kras-mutant mice. However, the pathophysiological and molecular mechanisms remained unknown and in particular it was unclear whether hyperinsulinemia affected PanIN precursor cells directly or indirectly.