Yizhou Zhuo

1 month ago | nature.com | Zhiyu Tian |Ryunosuke Amo |Yizhou Zhuo |Malcolm Campbell |Naoshige Uchida

AbstractResponding appropriately to potential threats before they materialize is critical to avoiding disastrous outcomes. Here we examine how threat-coping behavior is regulated by the tail of the striatum (TS) and its dopamine input. Mice were presented with a potential threat (a moving object) while pursuing rewards. Initially, the mice failed to obtain rewards but gradually improved in later trials.

Jan 18, 2024 | cell.com | Mai-Anh T Vu |Eleanor Brown |Michelle J Wen |Christian A Noggle |Eleanor Brown |Zicheng Zhang | +11 more

Highlights•A new customizable, targeted, and dense micro-fiber array approach for behaving mice•Measurements and manipulations of distributed neural dynamics over large 3D volumes•Modality-specific patterns of striatum-wide dopamine release in response to salient stimuli•Spatial mapping of a behavioral function via serially targeted striatum stimulationsSummaryNeural population dynamics relevant to behavior vary over multiple spatial and temporal scales across three-dimensional volumes.