Yuan Zhou

Apr 22, 2024 | nature.com | Yuan Zhou |Yafei Zhang |Chang Chen |Jiaxin Long |Aoxi Wang

Topological solitons, renowned for their stability and particle-like collision behaviors, have sparked interest in developing macroscopic-scale information processing devices. However, the exploration of interactions between multiple topological solitons in mechanical systems remains elusive. In this study, we construct a topological mechanical lattice supporting static vector solitons that represent quantized degrees of freedom and can freely propagate across the system. Drawing inspiration from coupled double atomic chains with sublattice symmetry breaking, we design a mechanical analogue featuring topologically protected boundary modes and induce independent modes to finite motions along branched motion pathways. Through a continuum theory, we describe the evolution of boundary modes with vector solitons composed of superposed kink solutions, identifying them as minimum energy pathways on the rugged effective potential surface with multiple degenerate ground states. Our results reveal the connection between transformable topological lattices and multistable systems, providing insight into nonlinear topological mechanics. Topological solitons can be realised in a range of platforms that have the potential for processing topologically protected information. Here, the authors identify a class of vector solitons in a mechanical lattice, showing superposed kinks and invertible polarizations, with implications for nonlinear topological mechanics.

Mar 21, 2024 | mdpi.com | Mengyu Wang |Guanqun Wang |Yong Hu |Yuan Zhou

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Feb 22, 2024 | biorxiv.org | Chunfeng He |Yue Xu |Yuan Zhou |Jiayao Fan

AbstractGenetics-informed drug repositioning presents a streamlined and cost-efficient way to broaden therapeutic options. However, leveraging the full spectrum of molecular signatures remains underexplored. We introduce TReD (Transcriptome-informed Reversal Distance), integrating population-level disease signatures robust to reverse causality and cell-based drug-induced response profiles.

Feb 4, 2024 | onlinelibrary.wiley.com | Shixia Ji |Yuan Zhou |Jiawen Chen |Minghui Yang

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Nov 28, 2023 | genomemedicine.biomedcentral.com | Dan Zhou |Yuan Zhou |Yue Xu |Ran Meng |Eric R. Gamazon

The GWAS summary statistics for common variants were obtained from the Neale Lab (http://www.nealelab.is/uk-biobank) [19]. After quality control, variants with minor allele frequency (MAF) ≥ 0.05 were included. Up to 337,199 subjects were available, with the effective sample size varying with the trait. The genome-wide association statistics had been estimated using a linear model with sex and the first 10 principal components as covariates. We mapped the common variants to protein-coding genes.