Clinical Cancer Research

Clinical Cancer Research is a journal that focuses on groundbreaking studies in clinical and translational cancer research, connecting laboratory findings with clinical applications. It particularly welcomes clinical trials that assess new therapies, along with research on pharmacology and molecular changes or biomarkers that can indicate how patients will respond to treatment or if they might resist it. The journal also emphasizes the importance of laboratory and animal research on new medications and targeted agents that could pave the way for future clinical trials, as well as investigations into the mechanisms that drive cancer development, disease progression, and metastasis.

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English

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#89459

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#38652

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#80

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Articles

Accumulation of CD38 in Hybrid Epithelial/Mesenchymal Cells Promotes Immune Remodeling and Metastasis in Breast Cancer

Jan 24, 2025 | aacrjournals.org | den Hollander |Maria Gabriela

This content is only available via PDF. This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License .
Development and Evaluation of an Automated Multimodal Mobile Detection of Oral Cancer (mDOC) Imaging System to Aid in Risk-based Management of Oral Mucosal Lesions

Jan 16, 2025 | aacrjournals.org | San Antonio

This content is only available via PDF. This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License .
Evolutionary Pressures Shape Undifferentiated Pleomorphic Sarcoma Development and Radiotherapy Response

Jan 14, 2025 | aacrjournals.org | Thomas Jefferson |van de Rijn |Serey C.L

Radiotherapy is an integral component in the treatment of many types of cancer, with approximately half of cancer patients receiving radiotherapy. Systemic therapy applies pressure that can select for resistant tumor subpopulations, underscoring the importance of understanding how radiation impacts tumor evolution to improve treatment outcomes.
Lung Cancer Screening Uptake under the Revised United States Preventive Services Task Force Guideline: Assessing Disparities

Jan 9, 2025 | aacrjournals.org | S’ Disclosures |East Lansing

Table 3 shows unadjusted and adjusted OR for sociodemographic and health-related factors that were considered possible predictors of LCS uptake. In the adjusted model, participants of ages 65 to 79 years were 75% (OR, 1.75; 95% CI, 1.54–1.99) more likely to undergo LCS than their younger counterparts (i.e., 50–64 years). Female participants were 17% (OR, 0.83; 95% CI, 0.73–0.94) less likely to undergo LCS than their male counterparts.
Automated Breast Density Assessment for Full-Field Digital Mammography and Digital Breast Tomosynthesis

Jan 6, 2025 | aacrjournals.org | S’ Disclosures

In the era of precision prevention and tailored screening, there is an increasing emphasis on getting the right prevention to the right women at the right time and tailoring screening examination protocols to women based on individual risk. Underpinning this approach is the need for accurate risk assessments that can be generated and delivered in real time in the clinic (1).
Biological Age Acceleration and Colonic Polyps in Persons under Age 50

Dec 10, 2024 | aacrjournals.org | Liver Diseases

Epigenetic clocks can quantify DNA methylation by measuring the methylation levels at specific sites in the genome, which correlate with biological age (BA). Accelerated aging, where BA exceeds chronologic age, has been studied in relation to cancer development, but its utility in cancer prevention remains unclear. Accelerated aging holds promise as a tool to explain the increase in early-onset colorectal cancer (EOCRC).
spatialGE is a User-Friendly Web Application that Facilitates Spatial Transcriptomics Data Analysis

Dec 5, 2024 | aacrjournals.org | Kansas City

This content is only available via PDF. This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License .
Establishment of a Mesoamerican-Caribbean South-South Research Platform: Challenges in the Meriva (Curcuminoids) Gastric Cancer Chemoprevention Trial

Dec 3, 2024 | aacrjournals.org | San Juan |Puerto Rico |Mayo Clinic Rochester

Gastric adenocarcinoma (GAC) is the fourth leading global cause of cancer mortality and leading infection-associated cancer. High-incidence regions of GAC include Latin America and Eastern Asia. Immigrants from high-incidence regions maintain their GAC risk. GAC is a major U.S. cancer disparity, and its incidence rates are 2 to 10 times higher in non-White populations. Emerging guidelines recommend 3-year surveillance endoscopy for patients with high-risk gastric premalignant conditions (GPMC).
Construction and Validation of a Novel Forecasting Nomogram to the Risk of Colorectal Adenomas: Preventing Colorectal Cancer at Its Origin

Dec 3, 2024 | aacrjournals.org | P.R. China

Colorectal adenomas are responsible for the origin of most colorectal cancers. Early detection together with active intervention of colorectal adenomas plays a crucial role in the prevention of colorectal cancer. This study aimed to construct and validate a new nomogram for the forecasting of the risk of colorectal adenomas based on lifestyle risk factors that could offer potential benefits for colorectal cancer prevention.
Construction and Validation of a Novel Forecasting Nomogram to the Risk of Colorectal Adenomas: Preventing Colorectal Cancer at Its Origin

Dec 2, 2024 | aacrjournals.org | P.R. China

Colorectal cancer ranks as the third most prevalent cancer and the second leading cause of cancer-related death worldwide (1). In recent years, the incidence and mortality rates of colorectal cancer in China have increased owing to economic development and lifestyle changes (2).