The Journal of Clinical Investigation

3 weeks ago | jci.org | Scott Friedman

The worldwide challenge of metabolic dysfunction–associated steatotic liver disease (MASLD) and its more advanced form, metabolic dysfunction associated steatohepatitis (MASH), has crept into our world. Previously referred to as NAFLD and NASH, respectively, these illnesses affect 30%–40% of the world’s population and are not confined to developing countries, rather affecting all regions except sub-Saharan Africa (1, 2).

3 weeks ago | jci.org | Bernd Schnabl |Christopher J. Damman |Rotonya M. Carr

AbstractMetabolic dysfunction–associated steatotic liver disease (MASLD) is a major cause of liver disease worldwide, and our understanding of its pathogenesis continues to evolve. MASLD progresses from steatosis to steatohepatitis, fibrosis, and cirrhosis, and this Review explores how the gut microbiome and their metabolites contribute to MASLD pathogenesis.

3 weeks ago | jci.org | Ushma S. Neill

With this entry, the Conversations with Giants in Medicine series comes to a close. The JCI is heading in a new direction with its video content, and I too will be heading in a different career direction that makes it hard to continue the series with the same care. As is often noted, “All good things must come to an end.” To watch a supercut of the last question I asked each subject, “What other vocation could have kept you as motivated?” see the JCI website at https://www.jci.org/videos/cgms.

3 weeks ago | jci.org | Jiale Chen |Lin Zhu |Zhaohai Cui |Yuxin Zhang

AbstractNewborns exhibit a heightened vulnerability to inflammatory disorders due to their underdeveloped immune system, yet the underlying mechanisms remain poorly understood. Here we report that plasma spermidine is correlated with the maturity of human newborns and reduced risk of inflammation. Administration of spermidine led to the remission of neonatal inflammation in mice.

1 month ago | jci.org | Edda Spiekerkoetter |Rahul Kumar |Qadar Pasha |Brian Graham

AbstractPulmonary hypertension (PH) encompasses a heterogenous group of disorders with the common feature of increased pulmonary arterial pressures. Patients with PH associated with lung disease and/or hypoxia undergo immune-mediated vascular remodeling that includes thickening of the muscular layer surrounding arteries and arterioles. In this issue of the JCI, Kumar and colleagues examined the role of interstitial macrophages in a model of high-altitude PH.