The Limbic

The Limbic is a publication that operates independently and is designed for healthcare professionals. It provides up-to-date news and expert analysis that pertains to your field, all presented in a straightforward online format that's easy to digest.

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Revealed: 17 key contributors to post-PCI major bleeding

2 weeks ago | thelimbic.com | Emma Koehn

An Australian review has identified 17 key preoperative factors associated with in-hospital major bleeding after PCI, with renal disease, ACS and age making up the top three. Published in Heart, Lung and Circulation [link here], the review included 32 studies, with 100 independent factors mentioned as being significantly associated with in-hospital major bleeding and 17 of these variables appearing in more than 10% of the articles analysed.
New myelofibrosis treatment listed on PBS

4 weeks ago | thelimbic.com | Geir O'Rourke

Momelotinib is now available on the PBS for patients with myelofibrosis who have moderate to severe anaemia. The Pharmaceutical Benefits Advisory Committee (PBAC) recommended the listing after determining the JAK inhibitor demonstrated non-inferior effectiveness and safety compared to ruxolitinib, with specific benefits for anaemia management.
Occupational COPD diagnosis: ‘We need to do better’

1 month ago | thelimbic.com | Siobhan Calafiore

Comprehensive occupational histories should become a standard element of respiratory consultations to increase diagnosis of workplace-acquired COPD, the TSANZ ASM heard. Speaking at TSANZ 2025 on Saturday, Sydney-based respiratory physician Professor Deborah Yates stressed the importance of early diagnosis so that workers could be removed from harmful exposure, with the health benefits of doing so documented in industries such as coal mining and stonemasonry.
Is ‘rational compassion’ the answer to doctor burnout?

1 month ago | thelimbic.com | Geir O'Rourke

What exactly is burnout? And what truly causes it? Despite growing awareness of the issue in healthcare, these crucial questions remain surprisingly elusive. The next step of moving beyond burnout to foster fulfilment among health professionals feels further still. The statistics will be familiar to many. Even back in 2013, 32% of Australian doctors reported emotional exhaustion in a now-infamous beyondblue survey (link here).
Early-intermediate HCC survey: consistent practice

1 month ago | thelimbic.com | Mardi Chapman

The surveillance, diagnosis and management of early to intermediate hepatocellular carcinoma (HCC) in Australia is largely consistent with guidelines although decision-making is becoming more complex given the heterogeneity of disease and a rapidly evolving space. A case-based survey of 79 specialists, representing the typical make-up of a multidisciplinary HCC team, was conducted in meetings across six states.
UK physician training in disarray as hundreds given wrong exam results

2 months ago | thelimbic.com | Amanda Cameron

Physician training in the UK is in disarray after hundreds of would-be specialists have just learned that they were given the wrong exam results by the Royal College of Physicians (RCP) in 2023.
Altered skin lipid profile predicts eczema risk

2 months ago | thelimbic.com | Siobhan Calafiore

Reduced levels of protein-bound skin ceramides in early life might help predict the development of atopic dermatitis and inform prevention strategies, an Australian study suggests. Melbourne researchers, led by the University of Melbourne’s Allergy and Lung Health Unit, said their findings suggested these lipids might have a role in the pathogenesis of atopic dermatitis (AD) and be useful predictive biomarkers.
Specialists divided on AF management in advanced kidney disease

2 months ago | thelimbic.com | Geir O'Rourke

Cardiologists and renal physicians diverge sharply on management of AF in advanced kidney disease, with key differences in prescribing of antithrombotic therapy and oral anticoagulation, local data show. The findings highlight significant gaps in multidisciplinary care and limited collaboration between specialties, despite growing evidence supporting integrated care approaches, the researchers say.
Guidance needed on drug-induced erythrocytosis, researchers warn

2 months ago | thelimbic.com | Emma Wilkinson

Clinicians need better guidance on identification and treatment of drug-induced erythrocytosis, say researchers who did a review of current evidence. The team found several classes of medications associated with erythrocytosis, including testosterone, SGLT-2 inhibitors, tyrosine kinase inhibitors, erythropoietin, and anti-TB medications. But they found limited evidence to guide clinical practice.
Spironolactone shows promise as first-line acne therapy

2 months ago | thelimbic.com | Geir O'Rourke

Adult women with moderate to severe acne are more than twice as likely to achieve successful resolution with spironolactone compared to placebo or doxycycline, a systematic review and meta-analysis indicates. Coupled with a favourable safety profile, the agent’s demonstrated efficacy positions it as a valuable alternative to antibiotics in the evolving approach to acne management, the authors say.